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KMID : 1007520030120060625
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Food Science and Biotechnology
2003 Volume.12 No. 6 p.625 ~ p.630
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Bifidobacterium longum BL730 Confers Protective Potentials against Salmonella Infection to Mice
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Go, Yun-Young
Cho, Ik Hyun/Kim, Jee Eun/Kim, Jung Won/Lee, Jong Ik/Kim, Hyung Soo/Lee, Joong Bok
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Abstract
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In order to develop probiotics with protective activity against diarrheal diseases, two kinds of lactic acid bacteria (LAB), Lactobacillus casei E5 and Bifidobacterium longum BL730, were evaluated with a Salmonella infection model in mice. Each stran was administered orally to the mice for eight consecutive days, and one day after the last feeding, the mice were orally challenged with Salmonella enteritidis at a dose of LD_(100) and then observed for 21 days. The survival rates of the control group and L. casei E5-treated group were 14% and 71% of the B, longum BL730-treated group survived, respectively indicating that feeding BL730 has a protective effect against Salmonella infection. The possible immune mechanisms involved in this protective activity were investigated. The proliferative response of splenocytes with mitogens and the production of inflammatory cytokines from macrophages did not increase, whereas the concentration of secretory IgA (sIgA) in intestinal contents of the mice fed with BL730 was 2.5 times higher than that of the control group, suggesting that local intestinal immunity plays an important role in protecting against the Salmonella infection.
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KEYWORD
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